Leslie Floren, PharmD, PhD, MA

Associate Dean and Professor
P_Clinical Pharmacy
+1 415 514-3559

Leslie Carstensen Floren, PharmD, DABCP is an Associate Adjunct Professor of Bioengineering and Therapeutic Sciences (BTS) in the School of Pharmacy at UCSF, the Academic Coordinator and Director of Professional and Postdoctoral Educational Affairs in BTS as well as the co-Director of the NIH-funded, UCSF Clinical Pharmacology Fellowship Training Program. Her teaching responsibilities for the past several years have included, primarily, teaching pharmacokinetics/pharmacodynamics, clinical pharmacology and principles of drug development and regulatory sciences to a wide variety of students, including professional students in the PharmD program, Clinical Pharmacology Fellows, junior faculty members, and working professionals from industrial backgrounds. Teaching is one of her greatest pleasures and she has been honored to receive the School of Pharmacy Dean’s Recognition for Excellence in Teaching every year since 2005 and, in 2010, she received the highest honor in the School of Pharmacy for teaching, the Long Award for Excellence in Teaching. Dr. Floren has a keen interest in curriculum development, teaching methodology and assessment, educational technology and online education and will begin training in the School of Medicine 2012-2013 Teaching Scholars Program in order to develop innovative curricula, to implement novel teaching methods and to use technology in order to “bring to life” the principles of Pharmacokinetics, Pharmacodynamics and Clinical Pharmacology for a wide variety of students within and across disciplines and, ultimately, to have a positive impact on patient health. She also plans to conduct scholarly research that will demonstrate the utility of practice-based teaching methods in order to advance interdisciplinary pharmaceutical sciences education within UCSF, our local community and across the country.

Publications

Cancer Chemother Pharmacol

Pharmacokinetic/pharmacodynamic analysis of adjuvant pegylated interferon alpha-2b in patients with resected high-risk melanoma.

Daud AI, Xu C, Hwu WJ, Urbas P, Andrews S, Papadopoulos NE, Floren LC, Yver A, Deconti RC, Sondak VK.

Br J Cancer

Phase II trial of sagopilone, a novel epothilone analog in metastatic melanoma.

DeConti RC, Algazi AP, Andrews S, Urbas P, Born O, Stoeckigt D, Floren L, Hwang J, Weber J, Sondak VK, Daud AI.

Drug Metab Dispos

An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects Af

GR Tonn, SG Wong, SC Wong, MG Johnson, J Ma, R Cho, LC Floren, K Kersey, K Berry, AP Marcus, X Wang, B Van Lengerich, JC Medina, PG Pearson, and BK Wong.

Drug Metab Pharmacokinet

Pharmacokinetic Interactions between Cyclosporine and Protease Inhibitors in HIV+ Subjects.

LA Frassetto, Thai T, Aggarwal A, Bucher P, Jacobsen W, U Christians, LZ Benet, LC Floren.

Pediatrics

Nelfinavir pharmacokinetics in stable HIV-positive children: AIDS Clinical Trials Group Protocol 377.

LC Floren, A Wiznia , SA Hayashi, A Jaywardene, K Stanley, G Johnson, S Nachman, P Krosstad, F Aweeka.

Clin Pharmacol Ther

The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups.

L Mancinelli, L Frassetto, LC Floren, D Dressler, S Carrier, I Bekersky, LZ Benet, U Christians.

Ann Onc

Tamoxifen in liver disease: potential exacerbation of hepatic function.

LC Floren, MF Hebert, AP Venook, VC Jordan, A Cisneros, and KA Somberg.

CJHP

Pharmacogenetics: The clinical significance of cytochrome P450 polymorphisms.

C Cheng and LC Floren.

Pharmacol Ther

Metabolism and drug interactions of the 3-hydroxy-3methylglutaryl Coenzyme A reductase inhibitors in transplant patients: are the statins mechanistically similar?

U Christians, W Jacobsen and LC Floren.

Clin Pharmacol Ther

Tacrolimus oral bioavailability doubles with co-administration of ketoconazole.

LC Floren, I Bekersky, LZ Benet, QA Mekki, DE Dressler, JW Lee, JP Roberts, and MF Hebert.

Transplantationsmedizen

The clinical pharmacokinetics of macrolide immunosuppressants and its impact on the clinical management of organ transplantation.

U Christians, LC Floren, G Kirchner, and K-F Sewing.